This material is supplemental to Ford et al., "Curvature of clathrin coated pits driven by epsin" Nature, 419: 361-366 (.pdf).
The alpha 0 helices from 4 symmetry-related molecules of epsin ENTH bound to Ins(1,4,5)P3 contribute to the formation of a 4-helix bundle in the crystal, thereby burying the hydrophobic residues L6, M10 and I13 in a protected hydrophobic core. Another view of helix 0, (bottom) also shows how the hydrophobic residues align on the surface.
Link to crystallographic data table
Link to other supplemental data
McMahon lab home page